Age-Defying Duo
Age-Defying Duo
Age-Defying Duo
Age-Defying Duo
Age-Defying Duo
Age-Defying Duo


Age-Defying Duo

P.P. EP4151217

The Age-Defying Duo-which comprises a unique combination of The Skin Biotic supplement and The Power Serum-harnesses the power of next-gen probiotics and topical ingredients for a more youthful complexion, regardless of gender or skin type.
A first step towards The Skin Method, providing focused results that pave the way for comprehensive skin transformation.
190 £


Single purchase


- Free shipping over 60 £

How to use

Follow the below protocol.

The Skin Biotic:
Take 1 sachet a day, preferably in the morning, 30 minutes before breakfast, dissolved directly in the mouth or in a small amount of water.

The Power Serum:
In the morning and evening, apply a few drops on dry, cleansed skin to face and neck as well as the delicate eye area.


Clinically proven

Derm tested

Sensitive skin

Renewable sources

Local sources

Vegan friendly

Lactose free

Gluten free

Key Benefits1

1 Clinically proven

Randomised, double-blind, placebo-controlled independent clinical study (8 weeks study duration).
4 groups of 24 subjects each, enrolled by a board-certified dermatologist, according to specific inclusion and exclusion criteria (age between 45 and 65 years old, declarative sensitive skin, skin ageing from mild to moderate). Assessment of the product effects/efficacy after 4- and 8-week intake/use.

1 Percentage of subjects showing a significant improvement after 8 weeks (clinically measured parameters).
Endpoints are measured using techniques currently accepted in the cosmetic field while biases are minimized by procedure(s) standardization according to ISO 9001 QMS.

Drag the line and discover the results

Evidence-backed outcomes
Transformative results in 8 weeks


Before After 8 weeks


Up to 45% wrinkles and fine lines reduction1
Up to 34% reduction after 1 hour1
Over x5.1 improvement after 8 weeks using all the 4 products of The Skin Method2

Target: 63 years old subject with deep wrinkles
Protocol: exclusive use of The Skin Method over an 8-week period
Pictures in T0 (clinical study start) and T8 (after 8 weeks)

1 Results from the reference group that used all four active products of 'The Skin Method' in combination.

2 Comprehensive improvement provided by the synergy of all four active products of 'The Skin Method', compared to a combination of placebo solutions composed of one supplement and three topical products.

Giacomo Santus

'Our team has designed next-generation biomimetic ingredients, which we have meticulously crafted into each formula to fully leverage their potent and synergistic properties, enabling us to achieve maximum efficacy and safety with minimal compounds.'

Giacomo Santus
Science & Innovation Lead at AWvi

About the results

The AWvi Skin complex

P.P. EP4151217

Our proven results are powered by the AWvi Skin Complex—a proprietary and patented blend of nutraceutical and cosmeceutical ingredients, formulated at optimal dosages to counteract the ageing process across every layer of the skin.



Our formulas are intricately designed to embrace the complexity of the body's internal and external systems. We go beyond surface-level solutions by factoring in the 'interactome'—a complex interplay of genetic, microbial, and environmental influences that shape your health.



Through a biomimetic approach, we utilise medical-grade ingredients that mirror the body's own chemistry and biology. This ensures unparalleled effectiveness in every formula, bringing the best of science to your skin.



Each ingredient is meticulously developed for its unique role within each formula and its capacity to work synergistically across all formulas. The result is transformative, evidence-backed outcomes that work from the inside-out and the outside-in, amplifying the individual benefits of each component.

How it Works

The Skin Biotic

The Skin Biotic represents a groundbreaking nutraceutical innovation that capitalizes on the intricate interplay between the gut and the skin. This symbiotic relationship, often referred to as the 'gut-skin axis,' allows us to tap into the unique benefits of specific probiotic strains, thereby fostering comprehensive skin health, overall well-being, and an improved appearance, not confined to the face but extending to the entirety of the body.

Within our probiotic complex, which comprises three PROPRIETARY strains, lies the essence of our holistic approach. These strains have been carefully curated and fine-tuned to work in concert, culminating in a synergistic effect that maximizes skin-related advantages. By nurturing a harmonious microbiome balance, we bolster the skin's natural defense mechanisms while supercharging its regenerative prowess.

Furthermore, The Skin Biotic incorporates indispensable vitamins, notably Retinol and D-Biotin, strategically selected due to their pivotal roles in supporting skin cellular metabolism.

Our quest for excellence extends to the selection of probiotic strains, where we delve into the intricacies of DNA analysis. In our journey to uncover the most suitable strains, we have come to appreciate the vast diversity within the Lactobacillus genus. It is crucial to recognize that each strain within this extensive family possesses distinct characteristics and capabilities.

Our commitment to precision is exemplified by our approach, built upon two pillars: Integration and Correct Dosage.

We introduce ingredients that seamlessly integrate with the body's natural chemistry and biology. This ensures that our supplement becomes an integral part of your daily well-being, working in harmony with your system.

The emphasis on precise dosing is paramount. Achieve the optimal balance of ingredients, rather than relying on quantity, is the key to unlocking the full potential of our product. The probiotics must not only be alive but also present in the correct quantity when administered. The quantity of living organisms in a probiotic dose is indicated on the label and is typically measured in CFU (colony forming units). This quantity should align with the dosage used in the related clinical trial that proved the efficacy of the specific bacterial strain. Unlike some products that tout high CFU (colony-forming units) counts, we prioritize efficacy, understanding that excess can often lead to undesirable reactions.

Our unwavering commitment to quality extends to all AWvi products. We adhere to pharmaceutical-grade R&D and manufacturing practices (our internal nutraceutical production line being located within a GMP—Good Manufacturing Practice—pharmaceutical facility that is certified by the Italian Medicines Agency), ensuring the safety and longevity of our supplement, right up to their expiration date.

In essence, The Skin Biotic transcends the conventional supplement paradigm.

The Power Serum

The serum is reminiscent of something highly concentrated, nourishing, and specific. With our formula, our aim was to establish a new standard in terms of concentration and efficacy.

The Power Serum, comprised of only six ingredients, achieves extreme levels of concentration. From the next-generation hyaluronic acid we've developed to the water we've made highly active, it's a remarkable feature considering that in many serums, water generally constitutes over 70% of the formulation, yet isn't an active ingredient.

Firstly, did you know that our body produces hyaluronic acid throughout our life? We produce a lot as children, decreasing progressively as we age. We also know that hyaluronic acid is crucial for the skin to maintain hydration, with the ability to retain up to 1,000 times its weight in water, much like a sponge, to use a tangible example.

Starting with this basic fact and revisiting the role of water, we incorporated into our formulations a next-generation hyaluronic acid, immediately recognized by the body. Thanks to advanced biotechnologies, we've developed a polysaccharide composed of particles of various sizes: small, acting in the deeper parts of the skin; medium and large, working more on the surface. Each of these particles has a specific function. Through a continuous and controlled fermentation process, in terms of temperature and pressure, we managed to exploit all the peculiarities of the different molecular weights, each with its specific functionalities and benefits.

To enhance the efficacy of the active ingredients, including our hyaluronic acid, we formulated our serum using our fruit-regenerated water. For the serum, it comes from Organic Mandarin. This water has the unique feature of acting as a communication vector between the epidermis and the deeper layers of the skin, thanks to electromagnetic processes.

In short: cellular communications also travel through electromagnetic processes, or through salt. The saline part is in turn another important aspect for our body: too much salt, or too little, creates imbalances—this is very noticeable when we lose salts during the summer or during physical activity: the pressure shifts, causing imbalances. However, we don't want to delve into this topic from a physiological perspective; we're focusing solely on the epidermal level.

We assessed that certain types of salts—as natural as possible and recognizable by our body—could benefit the communication between epidermal cells, making them more alert and ready to communicate amongst themselves and receive messages.

The salts contained in our water ensure that the serum's other active ingredients are better absorbed by the skin, acting more effectively. The part that remains on the surface, together with the skin's microbiome, creates a protective film, an enriched barrier.

The Power Serum should be used with care daily, both for younger skin to prevent dryness and dehydration and delay the early signs of aging, and for more mature skin, aiming to enhance skin elasticity, reduce wrinkle depth, and restore a more youthful and radiant appearance.

Focus on supplement hero ingredients

L. Plantarum AW001

It improves skin hydration by increasing natural hyaluronic acid production.

It aids in producing essential lipids and proteins that strengthen the skin's protective layer, reducing susceptibility to environmental stressors and irritants.

It can modulate the skin's immune response, potentially reducing allergic reactions and other immune-related conditions.

It helps soothe skin inflammation and is beneficial in managing atopic dermatitis and sensitive skin.

This strain exhibits antimicrobial activity against harmful skin bacteria, essential in managing acne and bacterial skin infections, contributing to a healthier skin microbiome.

It also exhibits antioxidant properties, protecting skin cells from free radical damage. This protection helps reduce the signs of aging and environmental skin damage.

Focus on topical hero ingredients

Active Water

Most skincare products are composed largely of water (up to 90%, by volume), which serves primarily as a base. We have made this essential component an active ingredient.

Our active water is upcycled, extracted from the non-edible portions of organic Mediterranean green mandarins (The Power Serum) and red oranges (The Gentle Cleanser and The Active Cream).

Compared to demineralised or distilled water, our microbiologically pure water offers a protective effect against oxidation, UV rays, and pollution.

Our active water also has anti-inflammatory properties and forms a protective film that strengthens the skin barrier. Moreover, it contains a type of salt that is recognised by the body and assists in the absorption of other ingredients.

How to use

The Skin Biotic

Take 1 sachet a day, preferably in the morning, 30 minutes before breakfast, dissolved directly in the mouth or in a small amount of water.

The Power Serum

In the morning and evening, apply a few drops on dry, cleansed skin to face and neck as well as the delicate eye area.

Your Questions About AWvi

Why opt for an integrated solution like The Skin Method?

Our vision with The Skin Method was to create an integrated and compact solution tailored to address a multitude of specific skin concerns while ensuring holistic health benefits for every skin type. This objective is achieved through a comprehensive approach that works both from both the inside out and the outside in, leveraging the synergistic actions of our products for exponential benefits. Each of the four products in our launch collection plays a vital role in this system. They are not just individually potent, but also collectively transformative, offering a broad spectrum of benefits from nourishment and balance to protection and regeneration. This curated selection is formulated for all genders, all ages, and all skin types.

What does P.P.EP4151217 correspond to?

P.P.EP4151217 corresponds to the registration number at the European Patent Office (EPO) for the patent of which AWvi is the exclusive owner, aimed at protecting the genuine innovation represented by its solution combining oral and topical formulas. The innovative nature of this solution has undergone thorough verification by the relevant authorities based on extensive clinical tests.

What is biotech?

Biotech, at its core, is about innovation and precision—it's where lab-grown ingredients come to life. Picture a space where the ingenuity of nature meets the exactitude of science. Here, we're not just following nature's blueprint; we're enhancing it, making it more accessible and sustainable without stepping outside the bounds of ethical responsibility.
We develop ingredients that are grown within the controlled environments of our labs. This method allows us to ensure the highest purity and efficacy of every compound we derive. It's about harnessing the inherent power of natural elements, then refining and concentrating them, without the shadow of contaminants.
This approach is groundbreaking. Imagine having the essence of the most potent botanicals at your fingertips, without depleting natural resources or harming the ecosystem. These lab-grown marvels are not just replicas; they are improvements, optimized to provide you maximum benefit.
At AWvi, biotech is more than a methodology—it's a commitment to excellence, sustainability, and the art of science.



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Benefit measurement protocol

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