The Age-Defying Duo

P.P. EP4151217

The Age-Defying Duo delivers targeted, physiology-based support for the prevention and correction of visible skin ageing. Combining The Skin Biotic and The Power Serum, this integrated protocol addresses internal and external mechanisms underlying premature ageing, including chronic inflammation, oxidative stress, extracellular matrix decline and impaired epidermal renewal. The Skin Biotic acts systemically by modulating the gut microbiome through a combination of a meticulously dosed prebiotic, three proprietary probiotic strains and highly bioavailable forms of retinol and D-biotin.

These actives influence microbial activity, epithelial integrity and systemic inflammatory responses, contributing to long-term skin resilience and longevity. The Power Serum complements this action at the skin surface by delivering structured hydration, reinforcing barrier function and supporting collagen dynamics. Its biotech-derived actives, including a broad spectrum of sodium hyaluronate, target dehydration, loss of elasticity, uneven texture, discolouration and pigmentation.

Suitable for all skin types, The Age-Defying Duo enhances both internal and external repair processes, optimises skin function and builds sustained resistance to age-related decline. It can be complemented with other topical solutions in the AWvi range for additional functional support and broader skin protection and regeneration outcomes.

ALL SKIN TYPES  ∙  ALL GENDERS

€210,00

How to use

Skin Biotic

Take 1 sachet a day, preferably in the morning, 30 minutes before breakfast, dissolved directly in the mouth or in a small amount of water.

Power Serum

In the morning and evening, apply a few drops on dry, cleansed skin to face and neck as well as the delicate eye area.

How it works

Skin Biotic

The Skin Biotic represents a groundbreaking nutraceutical innovation that capitalizes on the intricate interplay between the gut and the skin. This symbiotic relationship, often referred to as the 'gut-skin axis,' allows us to tap into the unique benefits of specific probiotic strains, thereby fostering comprehensive skin health, overall well-being, and an improved appearance, not confined to the face but extending to the entirety of the body.

 

Within our probiotic complex, which comprises three PROPRIETARY strains, lies the essence of our holistic approach. These strains have been carefully curated and fine-tuned to work in concert, culminating in a synergistic effect that maximizes skin-related advantages. By nurturing a harmonious microbiome balance, we bolster the skin's natural defense mechanisms while supercharging its regenerative prowess.

 

Furthermore, The Skin Biotic incorporates indispensable vitamins, notably Retinol and D-Biotin, strategically selected due to their pivotal roles in supporting skin cellular metabolism.

 

Our quest for excellence extends to the selection of probiotic strains, where we delve into the intricacies of DNA analysis. In our journey to uncover the most suitable strains, we have come to appreciate the vast diversity within the Lactobacillus genus. It is crucial to recognize that each strain within this extensive family possesses distinct characteristics and capabilities.

 

Our commitment to precision is exemplified by our approach, built upon two pillars: Integration and Correct Dosage.

 

We introduce ingredients that seamlessly integrate with the body's natural chemistry and biology. This ensures that our supplement becomes an integral part of your daily well-being, working in harmony with your system.

 

The emphasis on precise dosing is paramount.

 

Achieve the optimal balance of ingredients, rather than relying on quantity, is the key to unlocking the full potential of our product. The probiotics must not only be alive but also present in the correct quantity when administered. 

 

The quantity of living organisms in a probiotic dose is indicated on the label and is typically measured in CFU (colony forming units). This quantity should align with the dosage used in the related clinical trial that proved the efficacy of the specific bacterial strain. Unlike some products that tout high CFU (colony-forming units) counts, we prioritize efficacy, understanding that excess can often lead to undesirable reactions.

 

Our unwavering commitment to quality extends to all AWvi products. We adhere to pharmaceutical-grade R&D and manufacturing practices (our internal nutraceutical production line being located within a GMP—Good Manufacturing Practice—pharmaceutical facility that is certified by the Italian Medicines Agency), ensuring the safety and longevity of our supplement, right up to their expiration date.

In essence, The Skin Biotic transcends the conventional supplement paradigm.

Power Serum

The serum is reminiscent of something highly concentrated, nourishing, and specific.

 

With our formula, our aim was to establish a new standard in terms of concentration and efficacy.

 

The Power Serum, comprised of only six ingredients, achieves extreme levels of concentration. From the next-generation hyaluronic acid we've developed to the water we've made highly active, it's a remarkable feature considering that in many serums, water generally constitutes over 70% of the formulation, yet isn't an active ingredient.

 

Firstly, did you know that our body produces hyaluronic acid throughout our life? We produce a lot as children, decreasing progressively as we age. We also know that hyaluronic acid is crucial for the skin to maintain hydration, with the ability to retain up to 1,000 times its weight in water, much like a sponge, to use a tangible example.

 

Starting with this basic fact and revisiting the role of water, we incorporated into our formulations a next-generation hyaluronic acid, immediately recognized by the body. 

 

Thanks to advanced biotechnologies, we've developed a polysaccharide composed of particles of various sizes: small, acting in the deeper parts of the skin; medium and large, working more on the surface. Each of these particles has a specific function. 

 

Through a continuous and controlled fermentation process, in terms of temperature and pressure, we managed to exploit all the peculiarities of the different molecular weights, each with its specific functionalities and benefits.

 

To enhance the efficacy of the active ingredients, including our hyaluronic acid, we formulated our serum using our fruit-regenerated water. For the serum, it comes from Organic Mandarin. This water has the unique feature of acting as a communication vector between the epidermis and the deeper layers of the skin, thanks to electromagnetic processes.

 

In short: cellular communications also travel through electromagnetic processes, or through salt. 

 

The saline part is in turn another important aspect for our body: too much salt, or too little, creates imbalances—this is very noticeable when we lose salts during the summer or during physical activity: the pressure shifts, causing imbalances. However, we don't want to delve into this topic from a physiological perspective; we're focusing solely on the epidermal level.

 

We assessed that certain types of salts—as natural as possible and recognizable by our body—could benefit the communication between epidermal cells, making them more alert and ready to communicate amongst themselves and receive messages.

 

The salts contained in our water ensure that the serum's other active ingredients are better absorbed by the skin, acting more effectively. The part that remains on the surface, together with the skin's microbiome, creates a protective film, an enriched barrier.

 

The Power Serum should be used with care daily, both for younger skin to prevent dryness and dehydration and delay the early signs of aging, and for more mature skin, aiming to enhance skin elasticity, reduce wrinkle depth, and restore a more youthful and radiant appearance.

Ingredients

Ingredients:

THE SKIN BIOTIC

FRUCTO-OLIGOSACCHARIDES, SWEETENER: MANNITOL, LIMOSILACTOBACILLUS REUTERI, LACTICASEIBACILLUS RHAMNOSUS, LACTIPLANTIBACILLUS PLANTARUM, VITAMIN A (RETINYL ACETATE), BIOTIN (D-BIOTIN).

 

THE POWER SERUM

CITRUS NOBILIS (MANDARIN ORANGE) FRUIT EXTRACT, PENTYLENE GLYCOL, SODIUM HYALURONATE, ECTOIN, SODIUM BENZOATE, POTASSIUM SORBATE.

Focus on topical hero ingredients:

Active Water

Most skincare products are composed largely of water (up to 85%, by volume), which serves primarily as a base. We have made this essential component an active ingredient.

 

Our active water is upcycled, extracted from the non-edible portions of organic Mediterranean green mandarins (The Power Serum) and red oranges (The Gentle Cleanser and The Active Cream).

 

Compared to demineralised or distilled water, our microbiologically pure water offers a protective effect against oxidation, UV rays, and pollution.

 

Our active water also has anti-inflammatory properties and forms a protective film that strengthens the skin barrier. Moreover, it contains a type of salt that is recognised by the body and assists in the absorption of other ingredients.

Biomimetic Hyaluronic Acid

Hyaluronic acid (HA) is a key molecule involved in skin moisture, with the ability to hold up to 1,000 times its weight in water.

 

Ours comes in a full spectrum of molecular sizes, mimicking the HA produced by the human body and better able to counteract its gradual, age-related decline.

 

Molecules of varying sizes penetrate the skin at different depths, with larger molecules working on the surface and smaller ones reaching deeper layers.

 

Our topical formulas contain HA molecules of one or more sizes, selected according to each product specific function.

 

Our HA works to enhance skin moisturisation and reinforce the skin barrier, contributing to an overall improvement in skin health. It also offers a direct lifting effect, stimulates collagen production, and induces synthesis of elastin in fibroblasts.

 

These actions increase skin elasticity and smoothness and decrease the depth of fine lines and wrinkles.

Ectoin

Ectoin is an amino acid derivative discovered in the desert, where it was found to protect microorganisms against extreme conditions.

 

Our purified ectoin is a biotech product, precisely characterised from a chemical and biological perspective. It is made by bio-fermenting a non-GMO bacterial strain selected for its ability to enhance skin health.

 

Our ectoin actively supports the restoration of skin homeostasis, fortifying skin’s microbiotic defences against environmental stressors and promoting the synthesis of skin-strengthening peptides.

 

It also promotes cell viability and enhances cell metabolism while improving skin texture and elasticity and reducing the appearance of fine lines and wrinkles.

Biomimetic Triglycerides

Triglycerides are naturally occurring compounds that help to maintain healthy skin by providing a source of energy for skin cells, preserving the skin’s protective barrier, and reducing skin irritation and redness with their anti-inflammatory properties. 

 

They also contribute to the formation of lipids that keep skin hydrated, preventing water loss and helping to maintain its structure and function.

 

Our triglycerides have similar properties to those that occur naturally within the body. Their biocompatibility ensures high penetration of both active and functional ingredients while making our formulas easier to apply and more comfortable on the skin.

 

Our triglycerides are derived exclusively from locally sourced Italian, non-GMO olives using purification, extraction, and isolation processes that reduce our carbon footprint.

Focus on supplement hero ingredients:

L. Plantarum AW001

It improves skin hydration by increasing natural hyaluronic acid production.

 

It aids in producing essential lipids and proteins that strengthen the skin's protective layer, reducing susceptibility to environmental stressors and irritants.

 

It can modulate the skin's immune response, potentially reducing allergic reactions and other immune-related conditions.

It helps soothe skin inflammation and is beneficial in managing atopic dermatitis and sensitive skin.

 

This strain exhibits antimicrobial activity against harmful skin bacteria, essential in managing acne and bacterial skin infections, contributing to a healthier skin microbiome.

 

It also exhibits antioxidant properties, protecting skin cells from free radical damage. This protection helps reduce the signs of aging and environmental skin damage.

L. Reuteri AW002

It plays a crucial role in mitigating oxidative stress in skin cells, which is a significant factor in the aging process. This action helps in reducing the appearance of wrinkles and other signs of aging.

 

It is also known for its potential to promote tissue regeneration, aiding in the skin's natural healing process and improving recovery from skin damage.

 

This strain is particularly effective in reducing skin inflammation, making it beneficial for conditions like acne, eczema, and psoriasis. Its production of substances like reuterin and histamine helps modulate immune responses, which is key in managing these inflammatory skin conditions.

 

Lactobacillus reuteri enhances the skin's barrier function by increasing ceramide production. Ceramides are essential lipids that help the skin retain moisture and protect against external irritants and pathogens, contributing to overall skin health and resilience.

L. Rhamnosus AW003

It enhances the skin's barrier function by improving tight junction protein production, crucial for protecting against pollutants and allergens.

 

It modulates immune responses, reducing allergic reactions and inflammation, beneficial for conditions like eczema and atopic dermatitis.

 

This probiotic balances the skin microbiome, inhibiting harmful bacteria, thereby improving skin health and resilience.

Its anti-inflammatory properties soothe inflamed skin, helping in conditions like acne and rosacea.
 

Additionally, Lactobacillus rhamnosus aids in skin hydration, enhancing natural moisture retention and reducing dryness.         
 

Its antioxidant properties protect against oxidative stress and free radical damage, slowing the aging process and mitigating environmental skin damage.

Retinol and D-Biotin

Retinol (Vitamin A) enhances skin cell turnover, leading to improved texture and tone.
It accelerates the shedding of dead skin cells and the generation of new ones, influencing gene expression related to skin health.

 

Aiding in collagen production, it's crucial for reducing wrinkles and enhancing firmness.

 

It also offers protection against environmental stressors like UV radiation and pollution, thanks to its antioxidant capabilities, and reduces hyperpigmentation and age spots, contributing to an even skin tone.

 

D-biotin (Vitamin B8) is critical for the production of fatty acids, forming the foundation of cell membranes and contributing to a healthy skin barrier and hydration.

 

It plays a role in fat metabolism and cell growth, essential for the overall health and appearance of the skin.

 

It may help in reducing skin inflammation and redness, beneficial for conditions like rosacea and eczema.

Clinically

proven

Derm
tested

Sensitive
skin

Renewable

sources

Local 

sources

Vegan 

friendly

Lactose 

free

Gluten 

free

Evidence-backed outcomes

Transformative results in 8 weeks

  • Clinical Results

  • Wrinkles

  • Fine lines

  • Moisturisation

  • Radiance

  • Smoothness

  • Elasticity

95%

reduction in wrinkles and fine lines

100%

increase in skin moisturisation

95%

increase in skin radiance

82%

increase in skin moothness

100%

improvement in skin elasticity

Percentage of subjects showing a significant improvement after 8 weeks (clinically measured parameters). Endpoints are measured using techniques currently accepted in the cosmetic field while biases are minimized by procedure(s) standardization according to ISO 9001 QMS.

  • IN

  • OUT

  • IN & OUT

The Skin Biotic only

A systemic inside-out approach that modulates skin physiology via the gut–skin axis, integrating microbial signalling, immune regulation, and metabolic pathways.

Topical solutions only

A targeted outside-in intervention reinforcing epidermal integrity, barrier function, and tissue renewal processes.

Combined approach

An integrated In & Out strategy activating concurrent systemic and dermal mechanisms, with clinically measured efficacy amplified by 2.1×

8-week clinical efficacy study performed according to 4 distinct protocols:

1. PLACEBO: Placebo supplement + Placebo topical solutions

2. IN: The Skin Biotic + Placebo topical solutions

3. OUT: Placebo supplement + AWvi topical solutions

4. IN + OUT: The Skin Biotic + AWvi topical solutions

BEFORE
AFTER

Clinically proven results

Wrinkles and fine lines reduction

Up to 45% wrinkles and fine lines reduction 1

Up to 34% reduction after 1 hour 1

Over x5.1 improvement after 8 weeks with the full 4-product Skin Method 2

Target: 63 years old subject with deep wrinkles
Protocol: exclusive use of The Skin Method over an 8-week period

Pictures in T0 (clinical study start) and T8 (after 8 weeks)

1. Results from the reference group that used all four active products of 'The Skin Method' in combination.
2. Comprehensive improvement provided by the synergy of all four active products of 'The Skin Method', compared to a combination of placebo solutions composed of one supplement and three topical products.

BEFORE
AFTER

Clinically proven results

Wrinkles and fine lines reduction

Up to 45% wrinkles and fine lines reduction 1

Over x5.1 improvement after 8 weeks with the full 4-product Skin Method 2

Target: 51 years old subject
Protocol: exclusive use of The Skin Method over an 8-week period

Pictures in T0 (clinical study start) and T8 (after 8 weeks)

1. Results from the reference group that used all four active products of 'The Skin Method' in combination.
2. Comprehensive improvement provided by the synergy of all four active products of 'The Skin Method', compared to a combination of placebo solutions composed of one supplement and three topical products.

BEFORE
AFTER

Clinically proven results

Moisturisation improvement

Up to 60% moisturisation increase 1

Over x3.2 improvement after 8 weeks with the full 4-product Skin Method 2

Target: 49 years old subject 
Protocol: exclusive use of The Skin Method over an 8-week period

Pictures in T0 (clinical study start) and T8 (after 8 weeks)

1. Results from the reference group that used all four active products of 'The Skin Method' in combination.
2. Comprehensive improvement provided by the synergy of all four active products of 'The Skin Method', compared to a combination of placebo solutions composed of one supplement and three topical products.

BEFORE
AFTER

Clinically proven results

Radiance improvement

Up to 68% radiance improvement 1

Over x5.0 improvement after 8 weeks with the full 4-product Skin Method 2

Target: 61 years old subject 
Protocol: exclusive use of The Skin Method over an 8-week period

Pictures in T0 (clinical study start) and T8 (after 8 weeks)

1. Results from the reference group that used all four active products of 'The Skin Method' in combination.
2. Comprehensive improvement provided by the synergy of all four active products of 'The Skin Method', compared to a combination of placebo solutions composed of one supplement and three topical products.

BEFORE
AFTER

Clinically proven results

Smoothness improvement

Up to 23% smoothness increase 1

Over x5.6 improvement after 8 weeks with the full 4-product Skin Method 2

Target: 65 years old subject 
Protocol: exclusive use of The Skin Method over an 8-week period

Pictures in T0 (clinical study start) and T8 (after 8 weeks)

1. Results from the reference group that used all four active products of 'The Skin Method' in combination.
2. Comprehensive improvement provided by the synergy of all four active products of 'The Skin Method', compared to a combination of placebo solutions composed of one supplement and three topical products.

BEFORE
AFTER

Clinically proven results

Elasticity improvement

Up to 19% elasticity increase 1

Over x5.5 improvement after 8 weeks with the full 4-product Skin Method 2

Target: 46 years old subject 
Protocol: exclusive use of The Skin Method over an 8-week period

Pictures in T0 (clinical study start) and T8 (after 8 weeks)

1. Results from the reference group that used all four active products of 'The Skin Method' in combination.
2. Comprehensive improvement provided by the synergy of all four active products of 'The Skin Method', compared to a combination of placebo solutions composed of one supplement and three topical products.

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The Age-Defying Duo

€210,00